This guide contains information about places where you can stop for the night when driving from Los Angeles, California to Myrtle Beach, South Carolina. Total distance for the trip is around 2535 miles with a driving time of approximately 1 day 12 hours. Cities and towns with hotels that are on the fastest route between Los Angeles and Myrtle Beach are listed and shown on the map. (Driving times are approximate and will vary with traffic and weather conditions.)