This guide contains information about places where you can stop for the night when driving from Indianapolis, Indiana to Myrtle Beach, South Carolina. Total distance for the trip is around 767 miles with a driving time of approximately 11 hours 31 mins. Cities and towns with hotels that are on the fastest route between Indianapolis and Myrtle Beach are listed below. (Driving times are approximate and will vary with traffic and weather conditions.)

166 miles from Indianapolis (2 hours 34 mins)
606 miles from Myrtle Beach (9 hours 12 mins)
Major hotel chains: Best Western, Days Inn, Holiday Inn Express, Fairfield Inn by Marriott, Hampton Inn, Staybridge Suites by Holiday Inn, Marriott Hotel Brands, Wyndham Brands

Popular Hotels In Myrtle Beach

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Please make sure you read your reservation's cancellation policy!
You'll be given this information with the available room rates after you select a hotel and specify dates. Many hotels have cancellation penalties associated with their best rates. Most offer "Book Now and Pay Later" options that are less restrictive, but slightly more expensive.