This guide contains information about places where you can stop for the night when driving from Topeka, Kansas to Myrtle Beach, South Carolina. Total distance for the trip is around 1204 miles with a driving time of approximately 17 hours 49 mins. Cities and towns with hotels that are on the fastest route between Topeka and Myrtle Beach are listed and shown on the map. (Driving times are approximate and will vary with traffic and weather conditions.)