This guide contains information about places where you can stop for the night when driving from Kansas City, Missouri to Myrtle Beach, South Carolina. Total distance for the trip is around 1141 miles with a driving time of approximately 16 hours 51 mins. Cities and towns with hotels that are on the fastest route between Kansas City and Myrtle Beach are listed and shown on the map. (Driving times are approximate and will vary with traffic and weather conditions.)