Road Trip Hotel Planning From Portsmouth, New Hampshire to Myrtle Beach, South Carolina

This guide contains information about places where you can stop for the night when driving from Portsmouth, New Hampshire to Myrtle Beach, South Carolina. Total distance for the trip is around 922 miles with a driving time of approximately 14 hours 21 mins. Cities and towns with hotels that are on the fastest route between Portsmouth and Myrtle Beach are listed below. (Driving times are approximate and will vary with traffic and weather conditions.)

Boston, MA Hotels

56.8 miles from Portsmouth (1 hour 3 mins)
874 miles from Myrtle Beach (13 hours 38 mins)
Major hotel chains: Comfort Inns, Courtyard by Marriott, Doubletree Hotels, Holiday Inn Express, Four Seasons Hotels, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Hampton Inn, Hyatt Hotels and Resorts, Kimpton Hotels, Marriott Hotels and Resorts, Mandarin Oriental Hotel Group, Ramada International, Ramada Plazas Limiteds and Inns, Residence Inn by Marriott, Ritz-Carlton Hotels, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, Westin Hotels and Resorts, Wyndham Hotels, Hilton Garden Inn, Hilton Hotel Brands, Hyatt Hotel Group, Marriott Hotel Brands, Wyndham Brands, Aloft Hotels, Element Hotels

Hartford, CT Hotels

150 miles from Portsmouth (2 hours 23 mins)
776 miles from Myrtle Beach (12 hours 6 mins)
Major hotel chains: Best Western, Days Inn, Homewood Suites By Hilton, Hilton Hotels and Resorts, Marriott Hotels and Resorts, Super 8, Residence Inn by Marriott, Radisson Hotels, Red Roof Inns, Staybridge Suites by Holiday Inn, Hilton Hotel Brands, Marriott Hotel Brands, Wyndham Brands

New Haven, CT Hotels

186 miles from Portsmouth (2 hours 55 mins)
741 miles from Myrtle Beach (11 hours 37 mins)
Major hotel chains: Courtyard by Marriott, Days Inn, Staybridge Suites by Holiday Inn, Marriott Hotel Brands, Wyndham Brands

New York, NY Hotels

264 miles from Portsmouth (4 hours 27 mins)
661 miles from Myrtle Beach (10 hours 14 mins)
Major hotel chains: Best Western, Clarion Hotels, Comfort Inns, Crowne Plaza Hotels, Courtyard by Marriott, Days Inn, Doubletree Hotels, Econo Lodge, Holiday Inn Express, Fairfield Inn by Marriott, Four Points Hotels by Sheraton, Four Seasons Hotels, Homewood Suites By Hilton, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Hilton International, Hampton Inn, Hyatt Hotels and Resorts, Kimpton Hotels, Marriott Hotels and Resorts, Mandarin Oriental Hotel Group, Residence Inn by Marriott, Radisson Hotels, Ritz-Carlton Hotels, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, TownePlace Suites by Marriott, Westin Hotels and Resorts, Wyndham Hotels, SpringHill Suites by Marriott, Staybridge Suites, Cambria Suites, Hilton Garden Inn, Hilton Hotel Brands, Hotel Indigo, Hyatt Hotel Group, Hyatt Place, Marriott Hotel Brands, Wyndham Brands, Aloft Hotels, Element Hotels

Newark, NJ Hotels

273 miles from Portsmouth (4 hours 31 mins)
653 miles from Myrtle Beach (10 hours 3 mins)
Major hotel chains: Courtyard by Marriott, Comfort Suites, Doubletree Hotels, Fairfield Inn by Marriott, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Howard Johnson, Marriott Hotels and Resorts, Ramada International, Ramada Plazas Limiteds and Inns, Staybridge Suites by Holiday Inn, Wyndham Hotels, SpringHill Suites by Marriott, Hilton Hotel Brands, Hotel Indigo, Marriott Hotel Brands, Wyndham Brands, Tryp by Wyndham

Philadelphia, PA Hotels

356 miles from Portsmouth (5 hours 50 mins)
572 miles from Myrtle Beach (8 hours 54 mins)
Major hotel chains: Courtyard by Marriott, Days Inn, Doubletree Hotels, Holiday Inn Express, Fairfield Inn by Marriott, Four Points Hotels by Sheraton, Homewood Suites By Hilton, Hilton Hotels and Resorts, Hampton Inn, Hyatt Hotels and Resorts, Kimpton Hotels, Marriott Hotels and Resorts, Microtel Inns, Residence Inn by Marriott, Ritz-Carlton Hotels, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, Westin Hotels and Resorts, Wyndham Hotels, Cambria Suites, Hilton Garden Inn, Hilton Hotel Brands, Hyatt Hotel Group, Marriott Hotel Brands, Wyndham Brands, Aloft Hotels, Home2 Suites by Hilton

Wilmington, DE Hotels

384 miles from Portsmouth (6 hours 9 mins)
545 miles from Myrtle Beach (8 hours 25 mins)
Major hotel chains: Courtyard by Marriott, Days Inn, Doubletree Hotels, Homewood Suites By Hilton, Residence Inn by Marriott, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, Westin Hotels and Resorts, Marriott Hotel Brands, Wyndham Brands

Newark, DE Hotels

393 miles from Portsmouth (6 hours 18 mins)
532 miles from Myrtle Beach (8 hours 14 mins)
Major hotel chains: Baymont Inn & Suites, Courtyard by Marriott, Comfort Suites, Days Inn, Holiday Inn Express, Four Points Hotels by Sheraton, Homewood Suites By Hilton, Hilton Hotels and Resorts, Hampton Inn, Ramada International, Super 8, Quality Inns, Ramada Plazas Limiteds and Inns, Red Roof Inns, TownePlace Suites by Marriott, SpringHill Suites by Marriott, Staybridge Suites, Hilton Hotel Brands

Baltimore, MD Hotels

449 miles from Portsmouth (7 hours 12 mins)
475 miles from Myrtle Beach (7 hours 20 mins)
Major hotel chains: Comfort Inns, Crowne Plaza Hotels, Courtyard by Marriott, Days Inn, Doubletree Hotels, Holiday Inn Express, Fairfield Inn by Marriott, Four Seasons Hotels, Homewood Suites By Hilton, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Hampton Inn, Hyatt Hotels and Resorts, Kimpton Hotels, Marriott Hotels and Resorts, Quality Inns, Residence Inn by Marriott, Radisson Hotels, Red Roof Inns, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, SpringHill Suites by Marriott, Staybridge Suites, Hilton Garden Inn, Hilton Hotel Brands, Hotel Indigo, Hyatt Hotel Group, Hyatt Place, Marriott Hotel Brands, Wyndham Brands, Home2 Suites by Hilton

Washington, DC Hotels

487 miles from Portsmouth (7 hours 54 mins)
435 miles from Myrtle Beach (6 hours 39 mins)
Major hotel chains: Comfort Inns, Courtyard by Marriott, Days Inn, Fairfield Inn by Marriott, Four Seasons Hotels, Homewood Suites By Hilton, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Howard Johnson, Hampton Inn, Hyatt Hotels and Resorts, Kimpton Hotels, Marriott Hotels and Resorts, Mandarin Oriental Hotel Group, Quality Inns, Residence Inn by Marriott, Ritz-Carlton Hotels, Staybridge Suites by Holiday Inn, Westin Hotels and Resorts, Cambria Suites, Hilton Garden Inn, Hilton Hotel Brands, Hyatt Hotel Group, Hyatt Place, Marriott Hotel Brands, Wyndham Brands

Fredericksburg, VA Hotels

546 miles from Portsmouth (8 hours 46 mins)
384 miles from Myrtle Beach (5 hours 47 mins)
Major hotel chains: Best Western, Clarion Hotels, Courtyard by Marriott, Comfort Suites, Days Inn, Econo Lodge, Holiday Inn Express, Fairfield Inn by Marriott, Homewood Suites By Hilton, Holiday Inn Hotels and Resorts, Hampton Inn, Super 8, Quality Inns, Residence Inn by Marriott, Red Roof Inns, Staybridge Suites by Holiday Inn, Travelodge, TownePlace Suites by Marriott, Hilton Garden Inn, Hyatt Place, Marriott Hotel Brands, Wyndham Brands

Richmond, VA Hotels

601 miles from Portsmouth (9 hours 32 mins)
327 miles from Myrtle Beach (4 hours 54 mins)
Major hotel chains: Best Western, Clarion Hotels, Courtyard by Marriott, Days Inn, Doubletree Hotels, Econo Lodge, Holiday Inn Express, Fairfield Inn by Marriott, Four Points Hotels by Sheraton, Homewood Suites By Hilton, Hilton Hotels and Resorts, Holiday Inn Hotels and Resorts, Hampton Inn, Marriott Hotels and Resorts, Super 8, Quality Inns, Residence Inn by Marriott, Red Roof Inns, Staybridge Suites by Holiday Inn, Sheraton Hotels and Resorts, Westin Hotels and Resorts, SpringHill Suites by Marriott, Hilton Hotel Brands, Hyatt Place, Marriott Hotel Brands, Wyndham Brands

Petersburg, VA Hotels

624 miles from Portsmouth (9 hours 52 mins)
305 miles from Myrtle Beach (4 hours 33 mins)
Major hotel chains: Comfort Inns, Days Inn, Econo Lodge, Holiday Inn Express, Hampton Inn, Super 8, Quality Inns, Staybridge Suites by Holiday Inn, Marriott Hotel Brands, Wyndham Brands

Roanoke Rapids, NC Hotels

684 miles from Portsmouth (10 hours 46 mins)
247 miles from Myrtle Beach (3 hours 49 mins)
Major hotel chains: Baymont Inn & Suites, Best Western, Holiday Inn Express, Hampton Inn, Quality Inns, Red Roof Inns, Hilton Garden Inn

Rocky Mount, NC Hotels

726 miles from Portsmouth (11 hours 19 mins)
211 miles from Myrtle Beach (3 hours 21 mins)
Major hotel chains: Comfort Inns, Courtyard by Marriott, Days Inn, Doubletree Hotels, Homewood Suites By Hilton, Holiday Inn Hotels and Resorts, Hampton Inn, Quality Inns, Residence Inn by Marriott, Staybridge Suites by Holiday Inn, Marriott Hotel Brands, Wyndham Brands

Fayetteville, NC Hotels

810 miles from Portsmouth (12 hours 29 mins)
120 miles from Myrtle Beach (2 hours 3 mins)
Major hotel chains: Baymont Inn & Suites, Comfort Inns, Courtyard by Marriott, Days Inn, Doubletree Hotels, Econo Lodge, Holiday Inn Express, Fairfield Inn by Marriott, Homewood Suites By Hilton, Holiday Inn Hotels and Resorts, Hampton Inn, Ramada International, Super 8, Quality Inns, Ramada Plazas Limiteds and Inns, Residence Inn by Marriott, Red Roof Inns, Staybridge Suites by Holiday Inn, TownePlace Suites by Marriott, SpringHill Suites by Marriott, Hilton Garden Inn, Marriott Hotel Brands, Wyndham Brands, Home2 Suites by Hilton

Popular Hotels In Myrtle Beach

Sands Beach Club Resort
9400 Shore Dr
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Fairfield Inn by Marriott Myrtle Beach Broadway at the Beach
3150 Oleander Drive
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Ocean Inn
805 S. Ocean Blvd
Myrtle Beach, SC 29582
Book it: Tonight - Tomorrow - Monday - More Dates

Carolina Winds
Oceanfront at 76th Ave. North
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Sea Hawk Motel
2801 S Ocean Blvd
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Forest Dunes Resort
5511 North Ocean Blvd
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

World Tour Golf Resort
2000 World Tour Blvd
Myrtle Beach, SC 29579
Book it: Tonight - Tomorrow - Monday - More Dates

Horizon at 77th
215 77th Ave N
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Palms Resort
2500 N. Ocean Blvd.
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Bluegreen Vacations Harbour Lights, Ascend Resort Collection
2690 Harbour Lights Resort
Myrtle Beach, SC 29579
Book it: Tonight - Tomorrow - Monday - More Dates

Jonathan Harbour
2611 S.Ocean Blvd
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

River Oaks by Palmetto Vacation Rentals
Various Addresses
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Beach House Golf and Racquet Club
6800 N Ocean Blvd
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Beachcomber Inn
1405 S. Ocean Blvd.
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Horizon at 77th by Palmetto Vacations
215 77th Avenue North
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Units at Carolinian Beach Resort by Elliott Beach Rentals
2506 North Ocean Boulevard
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Units at Caravelle Resort by Elliott Beach Rentals
6900 North Ocean Boulevard
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Units at Sands Ocean Club by Elliott Beach Rentals
9550 Shore Drive
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Units at Carolina Winds by Elliott Beach Rentals
200 76th Avenue North
Myrtle Beach, SC 29572
Book it: Tonight - Tomorrow - Monday - More Dates

Units at Beach Colony Resort by Elliott Beach Rentals
5308 North Ocean Boulevard
Myrtle Beach, SC 29577
Book it: Tonight - Tomorrow - Monday - More Dates

Book Hotels Online
or call 1-866-226-8756

Please make sure you read your reservation's cancellation policy!
You'll be given this information with the available room rates after you select a hotel and specify dates. Many hotels have cancellation penalties associated with their best rates. Most offer "Book Now and Pay Later" options that are less restrictive, but slightly more expensive.