This guide contains information about places where you can stop for the night when driving from Odessa, Texas to Myrtle Beach, South Carolina. Total distance for the trip is around 1495 miles with a driving time of approximately 21 hours 22 mins. Cities and towns with hotels that are on the fastest route between Odessa and Myrtle Beach are listed and shown on the map. (Driving times are approximate and will vary with traffic and weather conditions.)

129 miles from Odessa (1 hour 51 mins)
1367 miles from Myrtle Beach (19 hours 38 mins)
Major hotel chains: Holiday Inn Express, Hampton Inn, Microtel Inns, Staybridge Suites by Holiday Inn, Marriott Hotel Brands, Wyndham Brands
606 miles from Odessa (8 hours 29 mins)
892 miles from Myrtle Beach (12 hours 58 mins)
Major hotel chains: Courtyard by Marriott, Days Inn, Holiday Inn Express, Fairfield Inn by Marriott, Hampton Inn, Super 8, Quality Inns

Popular Hotels In Myrtle Beach

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You'll be given this information with the available room rates after you select a hotel and specify dates. Many hotels have cancellation penalties associated with their best rates. Most offer "Book Now and Pay Later" options that are less restrictive, but slightly more expensive.