This guide contains information about places where you can stop for the night when driving from Daytona Beach, Florida to Myrtle Beach, South Carolina. Total distance for the trip is around 447 miles with a driving time of approximately 6 hours 44 mins. Cities and towns with hotels that are on the fastest route between Daytona Beach and Myrtle Beach are listed below. (Driving times are approximate and will vary with traffic and weather conditions.)

Popular Hotels In Myrtle Beach

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Please make sure you read your reservation's cancellation policy!
You'll be given this information with the available room rates after you select a hotel and specify dates. Many hotels have cancellation penalties associated with their best rates. Most offer "Book Now and Pay Later" options that are less restrictive, but slightly more expensive.